I'm not going to pretend that I know loads about Eastern Michigan, because I don't; and I don't think anyone knows much apart from the fact that they aren't very good.
They've only played FCS teams so far, so no need to be worried by their 2-0 record. Apparently they have a decent running game, but Michigan should be able to dominate them in the trenches; I'd love to see UM hold them under 100 yards running.
On offense, look for Michigan to run the ball a lot themselves, especially if they already have a big lead going into halftime. I doubt we'll see too much of Denard; there's no point risking his fitness in the easiest game on the schedule. Hopefully one of the running backs can step up and gain some consistent yardage. Who knows, it might be Thomas Rawls; who is apparently set to get a few carries in this game.
Bottom line: it should be over by halftime.
Prediction: Michigan 52; Eastern Michigan 13